the effects of aerobic exercise on nf-κb and tnf-α in lung tissue of male rat

background: regular aerobic exercise improves the background: regular aerobic exercise improves the inflammatory status in different lung diseases. however, the effects of long-term aerobic exercise on the lung response have not been investigated. the present study evaluated the effect of aerobic exercise on the lung inflammatory. m aterials and methods: 12 adult male wistar rats were divided to 2 groups: a: control (n=6), b: aerobic exercise (five times per week for 4 week; n=6). the gene expression of nf-κb and tnf-α were analyzed in lung tissue by real time–pcr. in order to determine the significant differences between groups independent t-test were used. r es ults: aerobic exercise inhibited the gene expression of nf-κb and tnf-α. but there was no significant difference between a and b groups for tnf-α and nf-κb. conclusion: we conclude that four week aerobic exercise decrease inflammatory status in lung tissue. our results indicate a need for human studies that evaluate the lung responses to aerobic exercise.